|MALHOTRA, BHANU - Amity University Mumbai|
|KHARKWAL, HARSHA - Amity University Mumbai|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 9/8/2016
Publication Date: 1/26/2017
Citation: Malhotra, B., Kharkwal, H., Yadav, M.P. 2017. Cellulose based polymeric systems in drug delivery. In: Kharkwal, H., Srinvas, J., editors, Natural Polymers for Drug Delivery. Oxfordshire, UK: CABI. p. 10-21.
Technical Abstract: The pharmaceutical industry requires the development of biodegradable, biocompatible, non toxic, site specific drug delivery polymers, which can be easily coupled with drugs to be delivered orally, topically, locally, or parenterally. The use of the most abundant biopolymer, cellulose along with its derivatives is intended to develop sustainable controlled release dosage forms by their easy fabrication into hydrophilic matrices. This amalgamation of the use of natural polymers, their derivatives with the drugs has proved to be one of the most effective means of delivering complex drugs without any side effects to the target sites in the body. Both cellulose esters and ethers are well researched and exploited to be used as coatings in various tablet formulations. This chapter provides a detailed discussion of the use of cellulose and cellulose derivatives as a powerful biopolymeric materials in drug delivery to various sites in the body. It also discusses the intervention of nanotechnology to develop cellulose nanofibrils as powerful moieties for therapeutic drug delivery.