|Bearson, Bradley - Brad|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 4/11/2016
Publication Date: 2/22/2017
Citation: Brunelle, B.W., Bearson, B.L., Allen, H.K. 2017. Strategies for acquisition and dissemination of antibiotic-resistance genes in Salmonella. Book Chapter. p. 331-348. https://doi.org/10.1002/9781119139188.ch14.
Technical Abstract: Nontyphoidal Salmonella continues to be a major cause of human gastrointestinal illness worldwide because its myriad of agricultural, environmental, and human reservoirs can directly or indirectly lead to infection. In addition to its ubiquity, antibiotic resistance in Salmonella isolated from both humans and livestock contribute to increased disease severity compared to susceptible isolates in human patients. Antibiotic-resistant Salmonella is therefore an important health and food safety concern, and the mechanisms of antibiotic resistance gene evolution and transmission are explored in the current chapter. Salmonella has acquired and adapted many different strategies to survive antibiotic exposure, including antibiotic deactivation, target modification, and efflux. Resistance genes are then transferrable among Salmonella by horizontal gene transfer, which will also be described. Understanding the frequency of antibiotic-resistant Salmonella isolates, the mechanisms of resistance those isolates employ, and the means by which such isolates acquire and disseminate resistance genes is paramount to addressing this key public health issue.