|YOUN, UI JOUNG - University Of Hawaii|
|PARK, EUN-JUNG - University Of Hawaii|
|KONDRATYUK, TAMARA - University Of Hawaii|
|SANG-NGERN, MAYURAMAS - University Of Hawaii|
|WEI, YANZHANG - Clemson University|
|PEZZUTO, JOHN - University Of Hawaii|
|CHANG, LENG CHEE - University Of Hawaii|
Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/9/2016
Publication Date: 5/19/2016
Citation: Youn, U., Park, E., Kondratyuk, T.P., Sang-Ngern, M., Wall, M.M., Wei, Y., Pezzuto, J.M., Chang, L. 2016. Anti-inflammatory and quinone reductase inducing compounds from fermented noni exudates. Journal of Natural Products. 79(6):1508-1513.
Interpretive Summary: Noni juice is consumed as a dietary supplement and is reportedly therapeutic for diabetes, high blood pressure, and certain types of cancer. Three new compounds, together with 13 known compounds, were isolated and identified from fermented noni extracts. Their chemical structures and biological activities were elucidated. The isolated compounds were evaluated in anti-inflammatory and anticancer bioassays, and five of the compounds exhibited moderate to high levels of activity. This discovery of novel compounds furthers our understanding of the medicinal properties of noni juice and expands our cache of biologically active constituents from tropical plants.
Technical Abstract: A new fatty acid ester disaccharide, 2-O-(ß-D-glucopyranosyl)-1-O- (2E,4Z,7Z)-deca-2,4,7-trienoyl-ß-D-glucopyranose (1), a new ascorbic acid derivative, 2-caffeyl-3-ketohexulofuranosonic acid '-lactone (2), and a new iridoid glycoside, 10-dimethoxyfermiloside (5), were isolated along with thirteen known compounds (3, 4, and 6'16) from fermented noni juice (Morinda citrifolia). The structures of the new compounds, together with 3 and 4 were determined by 1D- and 2D- NMR experiments, as well as comparison with the physicochemical analyses. The isolated compounds were evaluated in an in vitro quinone reductase inducing 1 (QR1) and inhibitory effect on tumor necrosis factor alpha (TNF-a)-induced NF-'B activity. Compounds 2 and 16 showed moderate inhibitory activity against the TNF-a-induced NF-'B and compounds 4 and 8 exhibited considerable QR1 inducing activity.