Location: Healthy Processed Foods ResearchTitle: Antiobesity properties of mushroom polysaccharides – A Review
Submitted to: American Chemical Society Symposium Series
Publication Type: Abstract Only
Publication Acceptance Date: 10/29/2015
Publication Date: 3/16/2016
Citation: Friedman, M. 2016. Antiobesity properties of mushroom polysaccharides – A Review. American Chemical Society Symposium Series. Meeting Abstract.
Technical Abstract: Mushrooms are widely consumed for their nutritional and health benefits. To stimulate broader interest in the reported health-promoting properties of bioactive mushroom polysaccharides, this presentation will survey the chemistry (isolation and structural characterization) and reported antiobesity properties and associated antioxidative, anti-inflammatory, and imunostimulating activities. The following examples demonstrate the potential value of structurally different polysaccharides from several mushroom sources to alleviate obesity, an aspect that merits further study in humans. (a) The dietary supplement ReishiMax containing polysaccharides extracted from the medicinal mushroom Ganoderma lucidum can control growth and glucose uptake in 3T3-L1 adipocyte (fat) cells. (b) A water extract of Ganoderma lucidum reduced body weight, inflammation, and insulin resistance in mice fed a high-fat diet by modulating the composition of the gut microflora. (c) Pleurotus eryngii mushroom heteropolysaccharides inhibited insulin resistance, oxidative stress, and live dysfunction in mice fed a high-fructose diet. (d) Three polysaccharides from Pleurotus tuber-regium mushrooms exhibited antihyperglycemic properties and attenuated oxidative stress in diabetic rats on a high fat diet; and (e) Dietary supplementation of a mouse diet with chitosan derived from mushrooms decreased feed efficiency, fat mass and fat deposition in the liver and the muscle of obese mice. Possible mechanisms of the beneficial properties will be discussed.