Skip to main content
ARS Home » Research » Publications at this Location » Publication #32239

Title: ENHANCED HUMORAL AND CELL MEDIATED RESPONSES TO EIMERIA ACERVULINA FOLLOWING INOCULATIONS WITH MEROZOITE AND SPOROZOITE FRACTIONS

Author
item MARTIN ALISON
item AWADALLA SALWA
item LILLEHOJ HYUN S

Submitted to: BARC Poster Day
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/1994
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Identification and characterization of immunogenic coccidial antigens eliciting cell mediated as well as humoral immune responses are vital to effective vaccine development. In order to identify such antigens, merozoite and sporozoite fractions were separated by electrophoresis and injected into chickens. Several fractions from merozoites and sporozoites induced humoral or cell mediated responses that would be considered favorable. Those which are most promising elicited moderate to high responses to more than one measure, such as merozoite Fractions 2, 3, 4 and 5. These fractions were between 6000 and 43,000 kDa molecular weight. Sporozoite fractions, however, showed little agreement among the measures of immunogenicity. The lack of any fraction which was high for all three measures used here supports the hypothesis that different antigens preferentially stimulated different T cell subsets. Thus, vaccines against avian coccidiosis will probably need to include several epitopes, possibly from different developmental stages.