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United States Department of Agriculture

Agricultural Research Service

Title: ANALYSES OF MAB REACTIVE WITH PORCINE CD8)

Author
item Saalmuller A
item Aasted B
item Canals A
item Dominguez J
item Goldman Theresa
item Lunney, Joan
item Mauer S
item Pescovitz M D
item Pospisil R
item Salmon H

Submitted to: Veterinary Immunology and Immunopathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/1/1994
Publication Date: N/A
Citation: N/A

Interpretive Summary: Based on FCM analyses 6 mAb: 76-2-11 (#004), PT36B (#051), PT81B (#052), PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109) recognizing the porcine CD8 antigen were identified to cluster together in the T5 cluster. Epitope analyses using biotinylated mAb 11/295/33 (#108) and 76-2-11 (#004) led to the determination of two epitopes CD8a and CD8b, the first recognized by mAb 76-2-11 (#004), PT36B (#051) and PT81B (#052); second by mAb PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109). Because of missing data about the molecular mass of the antigen recognized by mAb PT36B (#051), PT81B (#052) and PG93A (#053), these mAb received the prefix "w" for their respective subcluster.

Technical Abstract: Based on FCM analyses 6 mAb: 76-2-11 (#004), PT36B (#051), PT81B (#052), PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109) recognizing the porcine CD8 antigen were identified to cluster together in the T5 cluster. Epitope analyses using biotinylated mAb 11/295/33 (#108) and 76-2-11 (#004) led to the determination of two epitopes CD8a and CD8b, the first recognized by mAb 76-2-11 (#004), PT36B (#051) and PT81B (#052); second by mAb PG93A (#053), 11/295/33 (#108) and 11/122/28 (#109). Because of missing data about the molecular mass of the antigen recognized by mAb PT36B (#051), PT81B (#052) and PG93A (#053), these mAb received the prefix "w" for their respective subcluster.

Last Modified: 05/25/2017
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