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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #319749

Research Project: Developmental Determinants of Obesity in Infants and Children

Location: Children's Nutrition Research Center

Title: Ghrelin receptor controls obesity by fat burning

item SUN, YUXIANG - Children'S Nutrition Research Center (CNRC)

Submitted to: Oncotarget
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/27/2015
Publication Date: 3/27/2015
Citation: Sun, Y. 2015. Ghrelin receptor controls obesity by fat burning. Oncotarget. 6(9):6470-6471.

Interpretive Summary:

Technical Abstract: Emerging evidence show that brown fat in the body produces heat to burn energy, thus prompting weight loss. Ghrelin is the only known hormone which increases appetite and promotes weight gain. We have reported that mice that lack the receptor which mediates the functions of ghrelin are lean. Our further investigation reveals that these mice have a higher body temperature and are more resistant to cold, due to improved brown fat function. These studies suggest that blocking the ghrelin system may serve as a unique anti-obesity strategy by enhancing heat production in brown fat.