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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #318930

Research Project: Developmental Determinants of Obesity in Infants and Children

Location: Children's Nutrition Research Center

Title: Redox regulation in cancer stem cells

Author
item Ding, Shijie - Nanjing Agricultural University
item Li, Chunbao - Nanjing Agricultural University
item Cheng, Ninghui - Children'S Nutrition Research Center (CNRC)
item Cui, Xiaojiang - Cedars-Sinai Medical Center
item Xu, Xinglian - Nanjing Agricultural University
item Zhou, Guanghong - Nanjing Agricultural University

Submitted to: Oxidative Medicine and Cellular Longevity
Publication Type: Review Article
Publication Acceptance Date: 2/10/2015
Publication Date: 2/10/2015
Citation: Ding, S., Li, C., Cheng, N., Cui, X., Xu, X., Zhou, G. 2015. Redox regulation in cancer stem cells. Oxidative Medicine and Cellular Longevity. 2:1-11.

Interpretive Summary:

Technical Abstract: Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis. Aberrant ROS burst and dysregulation of those ROS-dependent cellular processes are strongly associated with human diseases including many cancers. ROS levels are elevated in cancer cells partially due to their higher metabolism rate. In the past 15 years, the concept of cancer stem cells (CSCs) has been gaining ground as the subpopulation of cancer cells with stem cell-like properties and characteristics have been identified in various cancers. CSCs possess low levels of ROS and are responsible for cancer recurrence after chemotherapy or radiotherapy. Unfortunately, how CSCs control ROS production and scavenging and how ROS-dependent signaling pathways contribute to CSCs function remain poorly understood. This review focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells (CSCs). We updated recent advances in our understanding of ROS generation and elimination in CSCs and their effects on CSC self-renewal and differentiation through modulating signaling pathways and transcriptional activities. The review concludes that targeting CSCs by manipulating ROS metabolism/dependent pathways may be an effective approach for improving cancer treatment.