|FANG, YING - Kansas State University|
|LADINIG, ANDREA - University Of Veterinary Medicine|
|CHEN, NANHUA - Kansas State University|
|LI, YANHUA - Kansas State University|
|ROWLAND, R - Kansas State University|
|RENUKARADHYA, GOURAPURA - The Ohio State University|
Submitted to: Annual Review of Animal Biosciences
Publication Type: Review Article
Publication Acceptance Date: 5/28/2015
Publication Date: 11/20/2015
Publication URL: https://handle.nal.usda.gov/10113/62709
Citation: Lunney, J.K., Fang, Y., Ladinig, A., Chen, N., Li, Y., Rowland, R.R., Renukaradhya, G.J. 2015. Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune System. Annual Review of Animal Biosciences. 4:129-154.
Technical Abstract: This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis and control. Worldwide PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms and host immunity with special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and advances in vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally we highlight the gaps in our knowledge base, and the need for advanced molecular and immune tools, to stimulate PRRS research and field applications.