Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 7/15/2015
Publication Date: N/A
Interpretive Summary: Brucella spp are intracellular pathogens that causes reproductive losses in domestic livestock and which also causes zoonotic infections in people. In these manuscript, we describe the current global situation for brucellosis, review the various species and preferred hosts, discuss mechanisms that Brucella use to infect and evade immune detection, and the potential for food products to be a major route for human infection. This data will be of interest to regulatory personnel, people with interests in food product quality, livestock owners, and other parties with interests regarding public health.
Technical Abstract: Although Brucella spp. are known for causing reproductive losses in domestic livestock, they are also capable of infecting humans and causing clinical disease. Human infection with Brucella is almost exclusively a result of direct contact with infected animals or consumption of products made from unpasteurized milk. In this review, mechanisms that Brucella uses to infect and evade immune detection are discussed in context of its role as a foodborne illness. The current global epidemiologic situation with human brucellosis and current advances in knowledge are discussed. Brucellosis is one of the most significant zoonotics affecting public health globally, and in many instances, human infection occurs through food.