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ARS Home » Southeast Area » Gainesville, Florida » Center for Medical, Agricultural and Veterinary Entomology » Mosquito and Fly Research » Research » Publications at this Location » Publication #317297

Research Project: Biting Arthropod Surveillance and Control

Location: Mosquito and Fly Research

Title: Synthesis and larvicidal and adult topical activity of some hydrazide-hydrazone derivatives against Aedes aegypti

item AKDAG, KADRIYE - University Of Marmara
item KOCYIGIT-KAYMAKCIOGL, BEDIA - University Of Marmara
item TABANCA, NURHAYAT - University Of Mississippi
item ALI, ABBAS - University Of Mississippi
item ESTEP, ALDEN - University Of Florida
item Becnel, James
item KHAN, IKHLAS - University Of Mississippi

Submitted to: Marmara Pharmaceutical Journal
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/20/2014
Publication Date: 10/20/2014
Citation: Akdag, K., Kocyigit-Kaymakciogl, B., Tabanca, N., Ali, A., Estep, A., Becnel, J.J., Khan, I.A. 2014. Synthesis and larvicidal and adult topical activity of some hydrazide-hydrazone derivatives against Aedes aegypti. Marmara Pharmaceutical Journal. 18:120-125.

Interpretive Summary: Natural plant derivatives are an important source for new insecticides to control public health pests such as mosquitoes. Hydrazones are present in many bioactive compounds because of their various biological and clinical applications. In this study tthe possible pharmacological potential of new molecules that contain a hydrazide-hydrazone scaffold were evaluated for activity against the yellow fever mosquito Aedes aegypti. Several compounds showed good activity against mosquito larvae but were less effective against adult mosquitoes. These compounds are a possible source for the development of new insecticides for public health applications.

Technical Abstract: A series of novel hydrazide-hydrazone derivatives were synthesized and evaluated for their larvicidal and adult topical activity against Aedes aegypti. The proposed structures of all the synthesized compounds were confirmed using elemental analysis, UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Compounds 4a-h were screened in larval bioassays at concentrations of 100, 50 and 25 ppm in a dose dependent manner and data for their mortality was recorded. Among the tested compounds, 1-(4-nitrophenyl)-3-(4-{2- oxo-2-[2-(2-oxo-1,2-dihydro-3H-ylidene)hydrazinyl] ethyl} phenyl) urea (4b) showed noteworthy larvacidal activity against Aedes aegypti. Dose-response data of compound 4b showed LC50 and LC90 values of 30.5 (15.4 – 22.7) and 95.9 (73.8 – 139.4) ppm, respectively. Screening of compounds 4a-h at four doses by topical bioassay indicated a range of activity between 10000 and 1000 ppm.