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Title: Complete genome sequence of Campylobacter concisus ATCC 33237T and draft genome sequences for an additional eight well-characterized C. concisus strains

Author
item CORNELIUS, ANGELA - Institute Of Environmental Science And Research
item Miller, William - Bill
item LASTOVICA, ALBERT - University Of The Western Cape
item ON, STEVEN - Institute Of Environmental Science And Research
item FRENCH, NIGEL - Massey University
item VANDENBERG, OLIVIER - Free University Of Brussels
item BIGGS, PATRICK - Massey University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/9/2017
Publication Date: 7/20/2017
Citation: Cornelius, A.J., Miller, W.G., Lastovica, A.J., On, S.L., French, N.P., Vandenberg, O., Biggs, P.J. 2017. Complete genome sequence of Campylobacter concisus ATCC 33237T and draft genome sequences for an additional eight well-characterized C. concisus strains. Genome Announcements. 5:e00711-17. https://doi.org/10.1128/genomeA.00711-17.
DOI: https://doi.org/10.1128/genomeA.00711-17

Interpretive Summary: Campylobacter concisus is a member and type species of a related cluster of campylobacters termed the C. concisus group. Species in this group were isolated originally from the human oral environment, from patients with periodontal disease, gingivitis or from normal gum tissue. C. concisus group members were long considered to be innocuous human commensals that caused no disease. However, for C. concisus that original diagnosis has been modified considerably: C. concisus has been isolated from instances of human gastroenteritis (ranging from mild diarrhea to dysentery) and is increasingly associated with serious human illness, e.g. Crohn’s disease. C. concisus is a very diverse species and it is unknown whether the species as a whole has the potential to induce acute human illness or if this potential is restricted to certain subsets of strains within the species. It is also unknown whether C. concisus has always been associated with illnesses like Crohn’s disease and this association has only been identified through better culturing and detection methods, or whether C. concisus has acquired novel virulence genes that has enhanced its pathogenicity in recent years. This study generated chromosomal DNA sequences for nine C. concisus strains isolated from humans with a range of illnesses. Comparison of these DNA sequences with others generated elsewhere will address fundamental issues related to C. concisus biology.

Technical Abstract: This report includes the complete genome of the Campylobacter concisus type strain ATCC 33237T and the draft genomes of eight additional well characterized C. concisus genomes. C. concisus has been shown to be a genetically heterogeneous species and these nine genomes provide valuable information regarding the diversity within this taxa.