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ARS Home » Midwest Area » Peoria, Illinois » National Center for Agricultural Utilization Research » Renewable Product Technology Research » Research » Publications at this Location » Publication #314603

Title: DOPC liposomes doped with octadecylferulate

item Evans, Kervin
item Compton, David - Dave
item Laszlo, Joseph

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/20/2015
Publication Date: 8/20/2015
Citation: Evans, K.O., Compton, D.L., Laszlo, J.A. 2015. DOPC liposomes doped with octadecylferulate. American Chemical Society. AGFD 53.

Interpretive Summary:

Technical Abstract: Octadecyl ferulate, found in limit quantities in plants, is a natural phenolic derivative with the potential as a cosmeceautical, nutriceutical, and/or pharmaceutical ingredient because of its lipophilic and antioxidant properties. The current work demonstrates our ability to chemically synthesize and purify octadecyl ferulate to a 42% yield using solid acid catalyst and supercritical fluid chromatograph. Fluorescence leakage demonstrates that octadecyl ferulate stabilized liposomes against loss of internal contents. Molecular modeling suggests that the saturated acyl chain possibly spans the bilayer. DSC measurements indicate a 74°C melting phase transition for octadecyl ferulate. And, AFM imaging show that 5-mole% present in a lipid bilayer induced domain formation.