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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #313341

Research Project: Improving Public Health by Understanding Diversity in Diet, Body, and Brain Interactions

Location: Obesity and Metabolism Research

Title: The elusive endogenous adipogenic PPARy agonists: lining up the suspects

Author
item Hallenborg, Philip - University Of Copenhagen
item Petersen, Rasmus - University Of Copenhagen
item Newman, John
item Madsen, Llise - National Institute Of Nutrition And Seafood Research, Nifes
item Kristiansen, Karsten - University Of Copenhagen

Submitted to: Cell Metabolism
Publication Type: Review Article
Publication Acceptance Date: 11/10/2015
Publication Date: 12/15/2015
Citation: Hallenborg, P., Petersen, R.K., Newman, J.W., Madsen, L., Kristiansen, K. 2015. The elusive endogenous adipogenic PPARy agonists: lining up the suspects. Cell Metabolism. 61:149-162. doi: 10.1016/j.plipres.2015.11.002.

Interpretive Summary: The peroxisome proliferator-activated receptor gamma (PPARgamma) is a structure which interacts with genes in the nucleus of adipose cells which are regulated by binding small molecules (i.e. ligands). Ligand binding to PPARgamma activates this receptor early in adipogenesis, the process by which immature adipose cells gain the ability to store fat, and this event is thought to be critical for this change in tissue function. Although several fatty acids and their derivatives are known to bind and activate PPARgamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation in a living organism are still a matter of debate. Here we review recent data on proteins involved in ligand-production as well as possible endogenous, adipogenic agonists.

Technical Abstract: Centrally placed in the development of adipocytes is the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma). Ligand-mediated activation of PPARgamma happens early during adipogenesis and is thought to prime adipose conversion. Although several fatty acids and their derivatives are known to bind and activate PPARgamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation is still a matter of debate. Here we review recent data on proteins involved in ligand-production as well as possible endogenous, adipogenic agonists.