Submitted to: Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/9/2015
Publication Date: 5/1/2015
Citation: Kappes, M.A., Faaberg, K.S. 2015. PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity. Virology. 479-480C:475-486.
Interpretive Summary: Porcine reproductive and respiratory syndrome (PRRS) is the foremost disease of swine in the United States. Control and eradication of PRRS is largely hindered by the significant genetic and antigenic variability noted between strains, which is maintained by a rapid rate of evolution. The structure, replication, and recombination mechanisms of the PRRS virion are presented.
Technical Abstract: Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts to eliminate infection of herds through vaccination or other elimination strategies. The purpose of this review is to summarize the research on the virion structure, replication and recombination properties of PRRSV that have led to the extraordinary phenotype and genotype diversity that exists worldwide.