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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #311353

Research Project: Chemistry of Natural Products for Nutraceutical Use, Pest Management and Crop Development

Location: Natural Products Utilization Research

Title: 7a-hydroxfriedelan-3one-26-OL-29-OIC acid and other constituents from Pileostegia Viburnoids VAR. Glabrescens

Author
item Chen, Shen-huang - Hunan University Of Chinese Medicine
item Yu, Juan - Hunan University Of Chinese Medicine
item Li, Qin-wen - Hunan University Of Chinese Medicine
item Zhao, Jian-ping - University Of Mississippi
item Wedge, David
item Duke, Stephen
item Liao, Duan-fang - Hunan University Of Chinese Medicine
item Wang, Yu-hong - Hunan University Of Chinese Medicine
item Fronczek, Frank - Louisiana State University
item Khan, Ikhlas - University Of Mississippi
item Wang, Wei - Hunan University Of Chinese Medicine

Submitted to: Natural Product Communications
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/19/2016
Publication Date: 7/1/2016
Citation: Chen, S., Yu, J., Li, Q., Zhao, J., Wedge, D.E., Duke, S.O., Liao, D., Wang, Y., Fronczek, F.R., Khan, I.A., Wang, W. 2016. 7a-hydroxfriedelan-3one-26-OL-29-OIC acid and other constituents from Pileostegia Viburnoids VAR. Glabrescens. Natural Product Communications. 11(7):931-934.

Interpretive Summary: Bio-prospecting natural products allows discovery of new agrochemicals for pest management and chemistry. Following natural product leads offers an efficient approach to discovering and optimizing new herbicides for weed management. Often plants used worldwide in traditional medicines have not been evaluated as potential bio-pesticides or new plant growth regulators. Pileostegia viburnoides var.glabrescens is a traditional Chinese medicine plant used for treating traumatic injury and fractures. P. viburnoides var.glabrescens was evaluated for antifungal and herbicidal activity. N-Butanol extract from P. viburnoides var.glabrescens was shown to be active at higher concentrations to Agrostis (monocot) and less active against lettuce (dicots). Several pure compounds were separated by chromatography from n-butanol extract of P. viburnoides var.glabrescens and no antifungal activity was found.

Technical Abstract: The preliminary phytotoxic evaluations of a n-BuOH extract from traditional Chinese medicinal plant Pileostegia viburnoides var. glabrescens showed herbicidal activity against dicot Lactuca sativa (lettuce) and monocot Agrostis stolonifera (bentgrass). In order to identify the phytotoxic constituents in the P. viburnoides var. glabrescens, a systematic bioassay-guided fractionation of the n-BuOH extract was performed. Six active compounds, umbelliferone (1), skimmin (2), fraxin (3), 7-O-ß-D-glucopyranosyl-8-metoxynenzopyranone (4), sweroside (5) and alboside II (6) were obtained, together with six inactive compounds (7-12). Except for compounds 1 and 2, all the other compounds were obtained from this species for the first time, and the crystal structure of n-butyl-ß-D-fructophyranoside (7) was obtained for the first time.