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Research Project: INTEGRATED APPROACHES FOR IMPROVING AQUATIC ANIMAL HEALTH IN COOL AND COLD WATER AQUACULTURE

Location: Cool and Cold Water Aquaculture Research

Title: Complete genome sequence of Yersinia ruckeri str. CSF007-82, etiologic agent of enteric redmouth disease in salmonid fish

Author
item Nelson, Michael - UNIVERSITY OF CONNECTICUT
item Lapatra, Scott - CLEAR SPRINGS FOODS, INC.
item Welch, Timothy - Tim
item Graf, Joerg - UNIVERSITY OF CONNECTICUT

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/15/2014
Publication Date: 1/29/2015
Citation: Nelson, M.C., Lapatra, S.E., Welch, T.J., Graf, J. 2015. Complete genome sequence of Yersinia ruckeri str. CSF007-82, etiologic agent of enteric redmouth disease in salmonid fish. Genome Announcements. 3(1):e01491-14. DOI:10.1128/genomeA.01491-14.

Interpretive Summary: Aquaculture is a significant commercial activity in the United States and worldwide. Vaccines were developed in the 1970's to prevent infection and disease caused by the bacterial pathogen Yersinia ruckeri, however within the past several years outbreaks of disease attributed to vaccine resistant strains of Y. ruckeri have occurred. These new pathogenic strains have been identified as genetically different from strains used for vaccine development, however little is still known about the genetics and evolution of Y. ruckeri. Whole genome sequencing allows us to identify the genetic factors that allow Y. ruckeri to cause disease, as well as the ability to track the evolution of new strains, but relies on the availability of high quality complete sequences for analysis. We present the first complete genome sequence of a Y. ruckeri strain. The availability of this genome not only allows for a more complete analysis and identification of genetic factors that allow strains to cause disease but additionally provides a complete reference for comparison of other genomes to understand the evolution of this species.

Technical Abstract: We present the complete, closed and finished chromosomal and extra-chromosomal genome sequences of Y. ruckeri strain CSF007-82, etiologic agent of enteric red mouth disease in salmonid fish. The chromosome is 3,799,036 bp with a G+C content of 47.5% and encodes 3,530 predicted CDS, 7 ribosomal operons, and 80 tRNAs.