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ARS Home » Plains Area » Fargo, North Dakota » Edward T. Schafer Agricultural Research Center » Cereal Crops Research » Research » Publications at this Location » Publication #309588

Research Project: Enhancement of Hard Spring Wheat, Durum, and Oat Quality

Location: Cereal Crops Research

Title: Surface properties of semi-synthetic enteric coating films: Opportunities to develop bio-based enteric coating films for colon- targeted delivery

Author
item Sivapragasam, Nilushni - North Dakota State University
item Thavarajah, Pushparajah - North Dakota State University
item Ohm, Jae-bom
item Thavarajah, Dil - Clemson University

Submitted to: Bioactive Carbohydrates and Dietary Fibre
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/10/2014
Publication Date: 10/1/2014
Publication URL: http://handle.nal.usda.gov/10113/59709
Citation: Sivapragasam, N., Thavarajah, P., Ohm, J.-B., Thavarajah, D. 2014. Surface properties of semi-synthetic enteric coating films: Opportunities to develop bio-based enteric coating films for colon- targeted delivery. Bioactive Carbohydrates and Dietary Fibre. 4:139-143.

Interpretive Summary: This study investigated the surface properties of coating materials which were designed to help deliver bioactive compounds to colon without any alteration when passing through the stomach. The coating materials were produced by combining chemical components called nanoscale resistant starch, pectin, and carboxymethylcellulose. The surface properties of the coating materials were characterized by a high resolution microscopic technique called atomic force microscopy. The coating with pure nanoscale resistant starch was used as a control: these control showed poor surface properties compared to the other films. The coating films that were made up of nanoscale resistant starch and pectin (90:10), and nanoscale resistant starch and carboxymethylcellulose (10:90) showed very good surface properties to deliver the bioactive compounds to colon. Therefore, the results of study suggest that the nanoscale resistant starch in combination with pectin, and carboxymetylcellulose could be used to produce novel coating films with good surface properties for targeted delivery of bioactive compounds to the colon without disintegrating in stomach.

Technical Abstract: This study investigated the surface properties of the semi-synthetic enteric coating materials for potential colon- targeted bioactive delivery. The enteric coating materials were produced by combining nanoscale resistant starch, pectin, and carboxymethylcellulose. The surface properties of the coating materials were characterized by atomic force microscopy for barrier properties, physical stability, and the viscoelastic properties: the surface of the coatings was characterized in terms of root-mean square roughness (RMS), peak-to-valley height (Rz), surface skewness (Rsk), and surface kurtosis (Rku). The coating with pure nanoscale resistant starch was used as a control: these control showed poor surface properties compared to the other films. However, the enteric coating films with nanoscale resistant starch: pectin 90:10 and nanoscale resistant starch: carboxymethylcellulose 10:90, showed very good barrier properties, visoelasticity, and physical stability. Therefore, the results of study suggest that the nanoscale resistant starch in combination with pectin, and carboxymetylcellulose could be used to produce novel films with good surface properties towards targeted delivery of bioactive compounds to the colon.