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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #308389

Research Project: IDENTIFICATION OF DISEASE MECHANISMS AND CONTROL STRATEGIES FOR BACTERIAL RESPIRATORY PATHOGENS IN CATTLE

Location: Ruminant Diseases and Immunology Research

Title: Genome sequences of serotype A6 Mannheimia haemolytica isolates D174 and D38 recovered from bovine pneumonia

Author
item HAUGLUND, MELISSA - Boehringer Ingelheim Pharmaceuticals
item Tatum, Fred
item Bayles, Darrell
item MAHESWARAN, SAMUEL - University Of Minnesota
item Briggs, Robert - Bob

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/2/2015
Publication Date: 3/12/2015
Publication URL: http://handle.nal.usda.gov/10113/61593
Citation: Hauglund, M.J., Tatum, F.M., Bayles, D.O., Maheswaran, S.K., Briggs, R.E. 2015. Genome sequences of serotype A6 Mannheimia haemolytica isolates D174 and D38 recovered from bovine pneumonia. Genome Announcements. 3(2):e00093-15. DOI: 10.1128/genomeA.00086-15.

Interpretive Summary: Mannheimia haemolytica is a costly bacterial causative agent of pneumonia (shipping fever) in cattle. This bacterium responds to stress and concurrent respiratory viral infection by greatly elevated levels of infection in cattle nasal passages. Although serotypes 1, 2, and 6 are common among in cattle nasal passages, only serotypes 1 and 6 so respond and that is likely why these latter serotypes predominate in pneumonic disease. Whole genome sequencing was conducted to define the differences between the serotypes. This report describes the genomes of two serotype 2 strains. Comparison of these with the genomes of serotypes 1 and 6 will allow scientists to focus on factors related to the stress response and potentially lead to improved disease intervention strategies.

Technical Abstract: Here we report two genomes, one complete and one draft, from virulent bovine strains of Mannheimia haemolytica(strains D174 and D38)serotype A2 recovered prior to the field usage of modern antimicrobial drugs.