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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #307748
Title: Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes

Author
item LIU, ZHENZHEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item QIN, TINGYU - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item ZHOU, JILIN - Columbia University
item TAYLOR, ALLEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SPARROW, JANET - Columbia University
item SHANG, FU - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 12/1/2014
Publication Date: 1/15/2014
Citation: Liu, Z., Qin, T., Zhou, J., Taylor, A., Sparrow, J.R., Shang, F. 2014. Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genes. IN: Ash, J. Retinal Degenerative Diseases, Advances in Experimental Medicine and Biology. New York, Springer. 801:237-250.

Interpretive Summary:

Technical Abstract: The ubiquitin-proteasome pathway (UPP) plays an important role in regulating gene expression. Retinal pigment epithelial cells (RPE) are a major source of ocular inflammatory cytokines. In this work we determined the relationship between impairment of the UPP and expression of inflammation-related factors. The UPP could be impaired by oxidative stress or chemical inhibition. Impairment of the UPP in RPE increased the expression of several inflammatory cytokines, such as IL-6 and IL-8. However, the expression of monocyte chemoattractant protein-1 (MCP-1) and complement factor H (CFH) and was reduced upon impairment of the UPP. These data suggest that impairment of the UPP in RPE may be one of the causes of retinal inflammation and abnormal functions of monocyte and the complement system during the pathogenesis of age-related macular degeneration.