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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #305737

Title: A genome-wide association study for the incidence of persistent bovine viral diarrhea virus infection in cattle

item Casas, Eduardo
item HESSMAN, BILL - Haskell County Animal Hospital
item Keele, John
item Ridpath, Julia

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/19/2014
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Bovine Viral Diarrhea Viruses (BVDV) comprises a diverse group of viruses that causes disease in cattle. BVDV may establish both, transient and persistent infections depending on the developmental stage of the animal at exposure. The objective was to determine if genomic regions harboring single nucleotide polymorphisms (SNP) could be associated with presence or absence of persistent BVDV infection. A genome-wide association approach based on 777,000 SNP markers was used. Samples of animals identified as positive (n= 1,200) or negative (n= 1,200) for the presence of BVDV in skin samples (n= 1,200), were used. DNA samples were combined in 24 pools (100 animals per pool). One SNP, significant at the 5% genome-wide level (P = 9.41 x 10-8) was detected on chromosome 14, located at position 80,675,176 bases. Fifteen SNP, residing on chromosomes 1, 2, 6, 8, 10, 15, and 18, were moderately associated (P < 1 x 10-5) with persistent BVDV infection. These SNP reside within or in the vicinity of genes involved in several biological processes. Genes in which the significant SNP reside are known to be involved in events that moderate immune responses, signal transduction, RNA splicing, and DNA methylation. These processes may contribute to the animal’s ability to survive the persistent infection. Genomic regions identified in the present study are necessary to understand the disease in cattle.