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United States Department of Agriculture

Agricultural Research Service

Research Project: National Animal Germplasm Program

Location: Plant and Animal Genetic Resources Preservation

Title: Angus sattle at high altitude: Genetic relationships and initial genome-wide association analyses of pulmonary arterial pressure)

Author
item Cockrum, R
item Zeng,
item Berge, N
item Neary, J
item Garry, F
item Holt, T
item Blackburn, Harvey
item Thomas, T
item Speidel, S
item Garrick, D
item Enns, R
item Thomas, M

Submitted to: Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 4/4/2014
Publication Date: 4/4/2014
Citation: Cockrum, R.R., Zeng, Berge, N.F., Neary, J.M., Garry, F.B., Holt, T., Blackburn, H.D., Thomas, T., Speidel, S.E., Garrick, D.J., Enns, R.M., Thomas, M.G. 2014. Angus sattle at high altitude: Genetic relationships and initial genome-wide association analyses of pulmonary arterial pressure. Symposium Proceedings. World Congress of Genetics Applied to Livestock Production Vancouver, BC, Canada, Aug 17-22, 2014.

Interpretive Summary:

Technical Abstract: Records from yearling Angus (n = 10,647) cattle from elevation 2,340 m were used in genetic analysis of pulmonary arterial pressure (PAP). Bulls were developed within a grain-supplemented performance test, whereas heifers and steers were grazed. The BovineSNP50 Beadchip was used to genotype a subset of cattle (n = 1,690). Bulls had greater (P<0.001) yearling PAP values as compared to steers and heifers. Heritability ranged from 0.20 in heifers and steers to 0.31 ± 0.15 in bulls. Moderate positive genetic correlations were observed in PAP measures with heifers and bulls (0.64 ± 0.14) and steers (0.74 ± 0.37). Genomewide association analyses using multi-locus mixed model and Bayesian approaches revealed several QTL for PAP; however, no concordant SNP (P<0.001) were observed among males and females. Therefore, results suggest that PAP appears to be a polygenic trait influenced by sex and (or) growth.

Last Modified: 8/24/2016
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