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Research Project: Discovery and Development of Natural Product-based Weed Management Methods

Location: Natural Products Utilization Research

Title: Natural compounds as next generation herbicides

item Dayan, Franck
item Duke, Stephen

Submitted to: Plant Physiology
Publication Type: Review Article
Publication Acceptance Date: 4/2/2014
Publication Date: 4/30/2014
Publication URL:
Citation: Dayan, F.E., Duke, S.O. 2014. Natural compounds as next generation herbicides. Plant Physiology. 166:1090-1105.

Interpretive Summary:

Technical Abstract: Herbicides with new modes of action (MOAs) are badly needed because of rapidly evolving resistance to commercial herbicides, for which a new MOA has not been introduced for more than 20 years. The biggest pest management challenge for organic agriculture is the lack of effective natural product herbicides. The structural diversity and evolved biological activity of natural phytotoxins offer opportunities for the development of both directly-used natural compounds and synthetic herbicides with new target sties based on the structure of natural phytotoxins. Natural phytotoxins are also a source of discovery of new herbicide targets that can be the focus of traditional herbicide discovery efforts. The many examples of strong natural phytotoxins with MOAs other than those used by commercial herbicides indicate that there are herbicide molecular targets to be added to the current repertoire of commercial herbicide MOAs.