Submitted to: Meeting Abstract
Publication Type: Abstract only
Publication Acceptance Date: 4/1/2014
Publication Date: 4/17/2014
Citation: Cardenas Garcia, S., Miller, P.J., Afonso, C.L. 2014. Newcastle disease: current vaccine research [abstract]. Abstracts for the Pre-Congress, for ANECA p. 28. Interpretive Summary:
Technical Abstract: Newcastle disease (ND) is one of the most important infectious diseases that affect poultry due to its devastating economic impact and world-wide distribution and contribution towards malnutrition in countries that rely on production of village chickens as a source of animal protein. Besides biosecurity, vaccination is the key method utilized to control ND. While current commercial ND vaccines can protect against mortality and disease, they do not provide sterilizing immunity. Reports of ND outbreaks continue, especially in countries with endemic virulent strains of Newcastle disease virus (vNDV) and even in those that apply extensive vaccination programs. Such situations initiated controversy over the need to develop new ND vaccines, as it has been reported that current vaccines protect well when correctly administrated. In contrast, there is evidence that newer ND vaccines formulated with viruses matching the genotype of the challenge virus (homologous vaccines) are more efficient at decreasing virus shedding after challenge and inducing more specific humoral response against the challenge virus. One of the advantages of producing vaccines that lead to a greater reduction of the amount of challenge virus shed might be the subsequent decrease in the rates of transmission as it has been shown that the amount of virulent virus being shed directly correlates with bird to bird transmission. Therefore, developing homologous vaccines and improving vaccination protocols may confer better protection to the flocks, reduce the environmental load and decrease transmission.