Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/14/2014
Publication Date: 8/14/2014
Citation: Evans, K.O., Laszlo, J.A., Compton, D.L. 2014. Bilayer properties of hydroxytyrosol- and tyrosol-phosphatidylcholine lipids [abstract]. American Chemical Society. AGFD 229.
Technical Abstract: Tyrosol and hydroxytyrosol are the phytochemicals abundantly found in olive oil. Transphosphatidylation of tyrosol and hydroxytyrosol with dioleoylphosphocholine resulted in phospholipids with antioxidant properties. The ability of these phyto-phospholipids to form liposomes and supported bilayers were explored. The nanoscale forces (Van der Waals, hydrophobic force, electrostatic interactions) between lipid molecules limit the size of hydroxytyrosol-phosphatidylcholine liposomes to 86 ±7 nm in diameter; these forces also prove to make hydroxytyrosol- phosphatidylcholine liposomes quite robust and difficult to rupture on silica surfaces. Tyrosol- phosphatidylcholine, on the other hand, readily forms liposomes as small as 62 ±5 nm in diameter and will more easily rupture to form a supported bilayer. The rate of rupture on silica surfaces is demonstrated to be influenced by pH.