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Location: Infectious Bacterial Diseases Research

Title: Complete genome sequence of Mycobacterium avium subsp. paratuberculosis, isolated from human breast milk

item Bannantine, John
item Li, Lingling - Pennsylvania State University
item Mwangi, Michael - Pennsylvania State University
item Cote, Rebecca - Pennsylvania State University
item Garay, Juan - Pennsylvania State University
item Kapur, Vivek - Pennsylvania State University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/6/2014
Publication Date: 2/6/2014
Publication URL:
Citation: Bannantine, J.P., Li, L., Mwangi, M., Cote, R., Garay, J.A., Kapur, V. 2014. Complete genome sequence of Mycobacterium avium subsp. paratuberculosis, isolated from human breast milk. Genome Announcements. 2(1):1-2.

Interpretive Summary: Johne’s disease in livestock such as dairy cattle and sheep is caused by the bacterium Mycobacterium avium subspecies paratuberculosis (MAP). This veterinary pathogen has historically been resistant to genetic manipulation, such as creating mutations or introducing genetic material. However, new information can be obtained through genome sequencing of different strains of MAP. This information can then be used to determine how the pathogen evolved or which strains are more virulent. Here we report the draft genome sequences of six new MAP strains obtained from the USDA’s National Veterinary Services Laboratory. These sequences are now available publically and will be used as a resource by scientists conducting Johne’s disease studies.

Technical Abstract: Mycobacterium avium subsp paratuberculosis is the etiologic agent of Johne’s disease. We report the draft genome sequences of six M. avium subsp paratuberculosis isolates obtained from diverse hosts including bison, cattle and sheep. These sequences will deepen our understanding of host association and evolutionary scenario for this animal pathogen.