Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 1/15/2014
Publication Date: 4/30/2014
Citation: Raatz, S.K., Beals, K., Johnson, L., Picklo, M.J. 2014. Chronic intake of honey, sugar and high fructose corn syrup exert equivalent effects on glucose and insulin. Federation of American Societies for Experimental Biology Conference. 28:1039.4. Interpretive Summary:
Technical Abstract: Consumption of nutritive sweeteners is high with ‘added sugars’ intake from the WWEIA (2009-2010) survey in all individuals = 2 yr at 76.2 g or 295 kcal daily. Controversy continues regarding the metabolic effects of the source of sweetener. Our goal was to evaluate the glycemic and insulin effect of chronic consumption of honey, sucrose, and high fructose corn syrup (HFCS 55). A randomized, crossover designed study compared glucose and insulin responses in overweight and obese adults (n=46). Participants underwent an OGTT at baseline and after 2 weeks of a daily dose of 50 g of the assigned sweetener. All participants were asked to not consume any other sweeteners throughout the trial. A 1-2 week washout period was completed before cross-over assignment to another nutritive sweetener. Body weight was measured and blood samples for the OGTT were obtained at 0, 15, 30, 60, 90 and 120 minutes and glucose and insulin concentrations determined. The incremental area under the curve (iAUC) for glucose and insulin was determined by trapezoidal rule. Outcome data were analyzed by repeated measures ANOVA. There were no statistically significant differences between or within treatment for glucose or insulin iAUC at baseline or post-treatment. Body weight was unchanged by treatment. Chronic intake of honey, sugar and HFCS 55 exerted similar effects on glycemic and insulin responses assessed by OGTT in overweight and obese adults.