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United States Department of Agriculture

Agricultural Research Service

Research Project: ASTRAGALUS AND OXYTROPIS POISONING IN LIVESTOCK

Location: Poisonous Plant Research

Title: Induction and transfer of resistance to poisoning by Amorimia (Macagnia) septentrionalis in goats)

Author
item Duarte, Amelia
item Medeiros, Rosane
item Carvalho, Fabricio
item Lee, Stephen
item Cook, Daniel
item Pfister, James - Jim
item Costa, Valeria
item Riet-correa, Franklin

Submitted to: Journal of Applied Toxicology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/27/2012
Publication Date: 2/1/2014
Citation: Duarte, A.L., Medeiros, R.M., Carvalho, F.K., Lee, S.T., Cook, D., Pfister, J.A., Costa, V.M., Riet-Correa, F. 2014. Induction and transfer of resistance to poisoning by Amorimia (Macagnia) septentrionalis in goats. Journal of Applied Toxicology. 34(2):220-223.

Interpretive Summary: Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses of A. septentrionalis. We also show that resistance to poisoning by A. septentrionalis can also be achieved by the transfer of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA.

Technical Abstract: Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses of A. septentrionalis. We also show that resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA.

Last Modified: 8/24/2016
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