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Title: Molecular epidemiology of infectious laryngotracheitis: a review

item MENENDEZ, KIMBERLY - Virginia-Maryland Regional College Of Veterinary Medicine (VMRCVM)
item GARCIA, MARICARMEN - University Of Georgia
item Spatz, Stephen
item TABLANTE, NATHANIEL - Virginia-Maryland Regional College Of Veterinary Medicine (VMRCVM)

Submitted to: Avian Pathology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/13/2013
Publication Date: 1/24/2014
Publication URL:
Citation: Menendez, K.R., Garcia, M., Spatz, S.J., Tablante, N.L. 2014. Molecular epidemiology of infectious laryngotracheitis: a review. Avian Pathology. 43(2):108-117. DOI: 10.1080/03079457.2014.886004.

Interpretive Summary: The complete nucleotide sequence of falcon herpesvirus type I was determined using next-generation sequencing technologies. The data suggest that falcon id herpesvirus type I is closely related to anatid herpesvirus type I, the causative agent of duck plague. The analysis provides insight to the genes involved in pathogenicity.

Technical Abstract: Falconid herpesvirus type 1 (FHV-1) is the causative agent of falcon inclusion body disease, an acute, highly contagious disease of raptors. The complete nucleotide sequence of the genome of FHV-1 has been determined. The genome is arranged as a D-type genome with large inverted repeats flanking a unique short region and short inverted repeats of only 250 bp flanking a unique long region. The FHV-1 genome contains 131 predicted open reading frames that a greater than 100 codons in length. Phylogenetically, FHV-1 is closely related to Anatid herpesvirus 1 and both represent a phylogenetic unique clade of alphaherpesviruses that are distinct from the Itoviruses (PsHV-1 and GaHV-1) and Mardiviruses (GaHV-2, GaHV-3 and MeHV-1). The determination of the genomic sequence of FHV-1 provides the bases for functional analysis of this unique class of avian alphaherpesviruses.