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United States Department of Agriculture

Agricultural Research Service


Location: Jean Mayer Human Nutrition Research Center On Aging

Title: The impact of sarcopenia on the response to a physical activity intervention in older adults)

item Liu, Christine
item Leng, Iris
item Kritchevsky, Stephen
item Ding, Jingzhong
item Earnest, Conrad
item Ferrucci, Luigi
item Goodpaster, Bret
item Guralnik, Jack
item Hsu, Fang-chi
item Lenchick, Leon
item Fielding, Roger

Submitted to: Journal of the American Geriatrics Society
Publication Type: Abstract Only
Publication Acceptance Date: 2/7/2011
Publication Date: 5/11/2011
Citation: Liu, C., Leng, I., Kritchevsky, S., Ding, J., Earnest, C., Ferrucci, L., Goodpaster, B., Guralnik, J., Hsu, F., Lenchick, L., Fielding, R.A. 2011. The impact of sarcopenia on the response to a physical activity intervention in older adults. Journal of the American Geriatrics Society. Control ID: 1025329.

Interpretive Summary:

Technical Abstract: To determine if the changes observed in the Short Physical Performance Battery (SPPB) after a physical activity or health education intervention are influenced by sarcopenia status at baseline. Data were obtained from the Lifestyles for Interventions and Independence for Elders Pilot Study, a RCT that examined the effect of a 1 year physical activity intervention compared to a health education program on physical performance measures in older adults at high risk for future disability. At enrollment dual-energy x-ray absorptiometry was performed and the presence of sarcopenia was determined by two methods: 1. calculation of ALM/ht**2: subjects were sarcopenic if appendicular lean mass (ALM or lean mass of all extremities) adjusted for height was less than or equal to 5.45 kg/m**2 for women or less than or equal to 7.26 kg/m**2 for men 2. Calculation of residual value: subjects were sarcopenic if ALM adjusted for height and fat mass was in the lowest gender-specific quintile (20%). Primary outcome measured was SPPB score. The sample consisted of 177 older adults. 71% of the subjects were female and the mean age was 77.7+/-4.0 years. Mean BMI was 29.2+/-5.8 kg/m**2, and 78% were white. Mean SPPB score at entry was 7.7+/-1.3. 89 subjects were in the intervention arm and 88 subjects were in the control arm. 11.3% and 18.6% of the subjects were sarcopenic at baseline by the ALM/ht**2 and residuals methods, respectively. At 1 year follow-up, sarcopenic subjects tended to have a larger mean improvement in SPPB score compared to non-sarcopenic subjects, regardless of intervention arm. Although this finding was limited by sample size, this trend persisted with use of either the ALM/ht**2 or residuals method. These results suggest that sarcopenic older adults may gain a greater benefit from physical activity or health education when compared to their non-sarcopenic counterparts.

Last Modified: 05/26/2017
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