|WATERLAND, ROBERT - Children'S Nutrition Research Center (CNRC)|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 5/1/2012
Publication Date: 6/20/2012
Citation: Waterland, R.A. 2012. Nutritional epigenetics. In: Erdman, J.W., MacDonald, I.A., Zeisel, S.H., editors. Present Knowledge in Nutrition. 10th Edition. Oxford, UK: Wiley-Blackwell. p. 14-26.
Technical Abstract: This chapter is intended to provide a timely overview of the current state of research at the intersection of nutrition and epigenetics. I begin by describing epigenetics and molecular mechanisms of eigenetic regulation, then highlight four classes of nutritional exposures currently being investigated for their potential to induce epigenetic alterations: dietary pertubation of one-carbon metabolism, prenatal energy restriction/growth retardation, assisted reproductive technologies, and histone deacetylase inhibitors. The chapter concludes with a discussion of outstanding questions in the field, and an elaboration of epigenetic technologies available to nutrition scientists.