Location: Warmwater Aquaculture Research UnitTitle: Multidose pharmacokineetecs of orally administered florfenicol in channel catfish Ictalurus punctatus) Author
Submitted to: Journal of Veterinary Pharmacology and Therapeutics
Publication Type: Peer reviewed journal
Publication Acceptance Date: 7/6/2012
Publication Date: 8/8/2012
Citation: Gaunt, P.S., Langston, C., Gao, D., Adams, P., Crouch, L., Sweeny, D., Endris, R. 2012. Multidose pharmacokineetecs of orally administered florfenicol in channel catfish Ictalurus punctatus. Journal of Veterinary Pharmacology and Therapeutics. p. 1-5. Interpretive Summary: The pharmacokinetics of an oral dose of the antibiotic florfenicol after an oral dose in channel catfish was studied. Based on the results, an a oral dose of 10mg/kg of body weight for 10 days should be able to control bacterial pathogens in catfish which had an in vitro inhibitory concentration value of < 2.5µg/mL.
Technical Abstract: Plasma disposition of florfenicol in channel catfish was investigated after an oral dose (10mg/kg for 10 days) administered in freshwater at water temperatures ranging from 24.7 to 25.9°C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half-life (t1/2), the maximum concentration at steady-state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady-state (Css(min)), and Vc/F were 9.0 h, 9.72µg/mL, 8 h, 2.53µg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of < 2.5µg/mL.