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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #293238

Title: Epigenetics of inflammation, maternal infection and nutrition

Author
item Larson, Kate
item Brissette, Catherine - Medical University Of North Dakota
item Ghibri, Othman - Medical University Of North Dakota

Submitted to: Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/21/2014
Publication Date: 5/1/2015
Publication URL: http://handle.nal.usda.gov/10113/60865
Citation: Claycombe, K.J., Brissette, C., Ghibri, O. 2015. Epigenetics of inflammation, maternal infection and nutrition. Journal of Nutrition. 145(5):1109S-15S.

Interpretive Summary:

Technical Abstract: Studies have demonstrated that epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling are linked to an increased inflammatory response as well as increased risk for chronic disease development. A few studies have begun to investigate whether dietary nutrients play a beneficial role by modifying or reversing epigenetic induced inflammation. Results of these studies show that nutrients modify epigenetic pathways. However, little is known about how nutrients modulate inflammation by regulating immune cell function and/or immune cell differentiation via epigenetic pathways. This overview will provide information about the current understanding of the role of nutrients in the epigenetic control mechanisms of immune function.