|MITCHUM, MELISSA - UNIVERSITY OF MISSOURI|
|HUSSEY, RICHARD - UNIVERSITY OF GEORGIA|
|DAVIS, ERIC - NORTH CAROLINA STATE UNIVERSITY|
|BAUM, THOMAS - IOWA STATE UNIVERSITY|
|ELLING, AXEL - WASHINGTON STATE UNIVERSITY|
Submitted to: New Phytologist
Publication Type: Review Article
Publication Acceptance Date: 4/5/2013
Publication Date: 5/21/2013
Citation: Mitchum, M.G., Hussey, R.S., Davis, E.L., Baum, T.J., Wang, X., Elling, A.A., Wubben, M. 2013. Nematode effector proteins: an emerging paradigm of parasitism. New Phytologist. 199(4):879-894. DOI: 10.1111/nph.12323.
Technical Abstract: Phytonematodes use a stylet and secreted effectors to invade host tissues and extract nutrients to support their growth and development. The molecular function of nematode effectors is currently the subject of intense investigation. In this review, we summarize our current understanding of nematode effectors, with a particular focus on proteinaceous stylet-secreted effectors of sedentary endoparasitic phytonematodes, for which a wealth of information has surfaced in the past ten years. We provide an update on the effector repertoires of several of the most economically important genera of plant-parasitic nematodes and discuss current approaches to dissect their function. Lastly, we highlight the latest breakthroughs in effector discovery that promise to shed new light on effector diversity across the phylum Nematoda.