|Shea, M kyla|
Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract only
Publication Acceptance Date: 2/13/2013
Publication Date: 4/9/2013
Citation: Prokopy, M.P., Booth, S.L., Saltzman, E., Yeum, K., Nicklas, B.J., Shea, M. 2013. Fat-soluble vitamin status in response to non-surgical weight loss in overweight post-menopausal women. Federation of American Societies for Experimental Biology Conference. 27:360.5. Interpretive Summary:
Technical Abstract: Obesity is associated with an increased risk of fat soluble vitamin (FSV) deficiencies. The effect of dietary weight loss on FSV status is uncertain. We measured plasma concentrations of carotenoids, alpha-tocopherol, retinol, phylloquinone, and 25-hydroxyvitamin D (25(OH)D) in 112 overweight post-menopausal women (mean(SD) BMI=33.1(3.7) kg/m**2) who participated in a 20-week hypocaloric weight-loss intervention. Mean(SD) weight loss was -12.1(4.5) kg. All women received 200 IU/day vitamin D3. Except for 25(OH)D, the same FSVs were measured in adipose tissue. Using repeated measures ANOVA adjusted for the respective baseline FSV concentration and potential confounders, the following plasma FSVs increased significantly post-intervention (all p<0.01): 25(OH)D (median increase 8.0 to 9.0 nmol/l), alpha-carotene (0.09 to 0.13 micromol/l), and cryptoxanthin (0.11 to 0.13 micromol/l). The other FSV concentrations in plasma and adipose tissue generally increased but changes were not statistically significant (all p>0.05). Modest weight loss achieved through caloric restriction was associated with modest increases in some FSV concentrations, although the clinical relevance is uncertain.