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United States Department of Agriculture

Agricultural Research Service


Location: Arkansas Children's Nutrition Center

Title: Persistent effects of a soy diet in early development on bone in female rats

item Zhang, Jian
item Lazarenko, Oxana
item Badger, Thomas
item Ronis, Martin
item Chen, Jin-ran

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 2/13/2013
Publication Date: 4/15/2013
Citation: Zhang, J., Lazarenko, O.P., Badger, T.M., Ronis, M.J., Chen, J. 2013. Persistent effects of a soy diet in early development on bone in female rats [abstract]. FASEB Journal. 27(Meeting Abstracts):233.7.

Interpretive Summary:

Technical Abstract: We have previously reported that feeding soy protein isolate (SPI) diet to pre-pubertal animals had a beneficial effect on bone accretion. However, it currently remains unclear whether the positive effects of SPI diet on bone in early life will persist to adulthood. In the present study, we fed postnatal day (PND) 24 weanling female rats with SPI diet for 30 days, and on PND 55 we switched SPI diet to a control casein diet until 6 months of age. At age 6 months, rats either underwent ovariectomy (OVX) or sham operation, and thereafter continued on control or SPI-diets for 1 or 3 weeks. Using peripheral quantitative CT scanning, we demonstrated that total bone mineral content and trabecular bone mineral density (BMD) were significantly increased in 30-day SPI-fed rats compared to their controls (p < 0.05). Both long-term (continuous) SPI (LT-SPI) and short-term (early life only) SPI (ST-SPI) diet protected against one week of OVX-associated bone loss. On the other hand, LT-SPI diet protected loss of total, trabecular, and cortical BMD 3 weeks after OVX, whereas ST-SPI diet only protected against cortical BMD loss (p < 0.05). These results suggest that ST-SPI diet has modest protective effects against sex-steroid deficiency-induced bone loss in adult females.

Last Modified: 10/17/2017
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