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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Avian Disease and Oncology Research » Research » Publications at this Location » Publication #288755

Research Project: EMPLOYING GENOMICS, EPIGENETICS, AND IMMUNOGENETICS TO CONTROL DISEASES INDUCED BY AVIAN TUMOR VIRUSES

Location: Avian Disease and Oncology Research

Title: Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease

Author
item LUO, JUAN - University Of Maryland
item YU, YING - China Agricultural University
item MITRA, APRATIM - University Of Maryland
item Zhang, Huanmin
item Liu, Ge - George
item SONG, JIUZHOU - University Of Maryland

Submitted to: Plant and Animal Genome Conference
Publication Type: Abstract Only
Publication Acceptance Date: 11/30/2012
Publication Date: 1/14/2013
Citation: Luo, J., Yu, Y., Mitra, A., Zhang, H., Liu, G., Song, J. 2013. Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0649. Avaliable: https://pag.confex.com/pag/xxi/webprogram/Paper5185.html.

Interpretive Summary:

Technical Abstract: Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was initially examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNV regions (CNVR) were found in 4 lines of chickens, and 28 of them were potentially involved in immune response and cell proliferation. More importantly, two CNVRs related with MD-resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may help to make a better strategy for MD resistance in poultry.