Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: EMPLOYING GENOMICS, EPIGENETICS, AND IMMUNOGENETICS TO CONTROL DISEASES INDUCED BY AVIAN TUMOR VIRUSES

Location: Avian Disease and Oncology Research

Title: Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease)

Author
item Luo, Juan
item Yu, Ying
item Mitra, Apratim
item Zhang, Huanmin
item Liu, Ge - George
item Song, Jiuzhou

Submitted to: Plant and Animal Genome Conference
Publication Type: Abstract only
Publication Acceptance Date: 11/30/2012
Publication Date: 1/14/2013
Citation: Luo, J., Yu, Y., Mitra, A., Zhang, H., Liu, G., Song, J. 2013. Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0649. Avaliable: https://pag.confex.com/pag/xxi/webprogram/Paper5185.html.

Interpretive Summary:

Technical Abstract: Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was initially examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNV regions (CNVR) were found in 4 lines of chickens, and 28 of them were potentially involved in immune response and cell proliferation. More importantly, two CNVRs related with MD-resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may help to make a better strategy for MD resistance in poultry.

Last Modified: 8/24/2016
Footer Content Back to Top of Page