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United States Department of Agriculture

Agricultural Research Service

Research Project: REGULATION OF ADIPOCYTE AND ADIPOSE TISSUE METABOLISM IN OBESITY RELATED INFLAMMATION AND METABOLIC DISORDERS

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis)

Author
item Greenberg, Andrew S.
item Kraemer, Fredric B.
item Soni, Krishnakant G.
item Jedrychowski, Mark P.
item Yan, Qing-wu
item Graham, Christine E.
item Bowman, Thomas A.
item Mansur, Ayla

Submitted to: EMBO Journal
Publication Type: Review Article
Publication Acceptance Date: 9/20/2011
Publication Date: 11/2/2011
Citation: Greenberg, A., Kraemer, F., Soni, K., Jedrychowski, M., Yan, Q., Graham, C., Bowman, T., Mansur, A. 2011. Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis. EMBO Journal. 30(21):4337-4339.

Interpretive Summary:

Technical Abstract: In response to adrenergic stimulation, adipocytes undergo protein kinase A (PKA)-stimulated lipolysis. A key PKA target in this context is perilipin 1, a major regulator of lipolysis on lipid droplets (LDs). A study published in this issue of The EMBO Journal (Pidoux et al, 2011) identifies optic atrophy 1 (OPA1), a protein that regulates mitochondrial dynamics, as perilipin 1 interaction partner and the A-kinase anchoring protein (AKAP) on LDs that is involved in the induction of stimulated lipolysis.

Last Modified: 05/22/2017
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