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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #285225

Title: Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis

Author
item Greenberg, Andrew S. - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Kraemer, Fredric B. - Stanford University
item Soni, Krishnakant G. - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Jedrychowski, Mark P. - Harvard University
item Yan, Qing-wu - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Graham, Christine E. - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Bowman, Thomas A. - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item Mansur, Ayla - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: EMBO Journal
Publication Type: Review Article
Publication Acceptance Date: 9/20/2011
Publication Date: 11/2/2011
Citation: Greenberg, A., Kraemer, F., Soni, K., Jedrychowski, M., Yan, Q., Graham, C., Bowman, T., Mansur, A. 2011. Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis. EMBO Journal. 30(21):4337-4339.

Interpretive Summary:

Technical Abstract: In response to adrenergic stimulation, adipocytes undergo protein kinase A (PKA)-stimulated lipolysis. A key PKA target in this context is perilipin 1, a major regulator of lipolysis on lipid droplets (LDs). A study published in this issue of The EMBO Journal (Pidoux et al, 2011) identifies optic atrophy 1 (OPA1), a protein that regulates mitochondrial dynamics, as perilipin 1 interaction partner and the A-kinase anchoring protein (AKAP) on LDs that is involved in the induction of stimulated lipolysis.