Location: Children's Nutrition Research CenterTitle: SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis Author
|Kim, Ki Woo|
Submitted to: Molecular and Cellular Endocrinology
Publication Type: Review Article
Publication Acceptance Date: 11/14/2010
Publication Date: 4/10/2011
Citation: Kim, K., Sohn, J., Kohno, D., Xu, Y., Williams, K., Elmquist, J.K. 2011. SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis. Molecular and Cellular Endocrinology. 336(1-2):219-223. Interpretive Summary:
Technical Abstract: The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene knock out approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.