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Title: Gene-gene and gene-environment interactions defining lipid-related traits

Author
item ORDOVAS, JOSE M. - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item ROBERTSON, RUAIRI - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item CLEIRIGH, ELLEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Current Opinion in Lipidology
Publication Type: Review Article
Publication Acceptance Date: 10/1/2010
Publication Date: 4/1/2011
Citation: Ordovas, J., Robertson, R., Cleirigh, E. 2011. Gene-gene and gene-environment interactions defining lipid-related traits. Current Opinion in Lipidology. 22(2):129-136.

Interpretive Summary:

Technical Abstract: Steps towards reducing chronic disease progression are continuously being taken through the form of genomic research. Studies over the last year have highlighted more and more polymorphisms, pathways and interactions responsible for metabolic disorders such as cardiovascular disease, obesity and dyslipidemia. Many of these chronic illnesses can be partially blamed by altered lipid metabolism, combined with individual genetic components. Critical evaluation and comparison of these recent studies is essential in order to comprehend the results, conclusions and future prospects in the field of genomics as a whole. Recent literature elucidates significant gene--diet and gene--environment interactions resulting in altered lipid metabolism, inflammation and other metabolic imbalances leading to cardiovascular disease and obesity. Epigenetic and epistatic interactions are now becoming more significantly associated with such disorders, as genomic research digs deeper into the complex nature of genetic individuality and heritability. The vast array of data collected from genome-wide association studies must now be empowered and explored through more complex interaction studies, using standardized methods and larger sample sizes. In doing so the etiology of chronic disease progression will be further understood.