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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCT FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

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Title: Exploring the molecular basis of antifungal synergies using genome-wide approaches)

Author
item Agarwal, Ameeta
item Tripathi, Siddharth
item Xu, Tao
item Jacob, Melilssa
item Li, Xing-cong
item Clark, Alice

Submitted to: Frontiers in Microbiology
Publication Type: Review article
Publication Acceptance Date: 3/12/2012
Publication Date: 3/27/2012
Citation: Agarwal, A.K., Tripathi, S.K., Xu, T., Jacob, M.R., Li, X., Clark, A.M. 2012. Exploring the molecular basis of antifungal synergies using genome-wide approaches. Frontiers in Microbiology. (3)15:1-6.

Interpretive Summary: This is a review article summarizing genomic profiling strategies for determining the mechanism of action of antifungal synergies, and highlighting the potential applications of these technologies. Given the limitations of currently available antifungal agents and the development of drug resistance, there is an urgent need for discovering new antifungal drugs, in particular drugs that can be used in combination therapies. Identifying the mechanism behind drug synergies is not only an important step towards drug development, but it also has the potential to generate new pharmacological tools for further exploration of the targeted pathways and understanding how they interact with each other.

Technical Abstract: This is a review article summarizing genomic profiling strategies for determining the mechanism of action of antifungal synergies, and highlighting the potential applications of these technologies. Given the limitations of currently available antifungal agents and the development of drug resistance, there is an urgent need for discovering new antifungal drugs, in particular drugs that can be used in combination therapies. Identifying the mechanism behind drug synergies is not only an important step towards drug development, but it also has the potential to generate new pharmacological tools for further exploration of the targeted pathways and understanding how they interact with each other.

Last Modified: 8/24/2016
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