Submitted to: Current Bioactive Compounds
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/1/2011
Publication Date: 12/20/2011
Citation: Xu, W., Li, X. 2011. Antifungal compounds from Piper species. Current Bioactive Compounds. 7(4):262-267. Interpretive Summary: This paper is a review documenting chemical structures and antifungal activities of 68 compounds isolated from 22 Piper species of the plant family Piperaceae. Some of them may serve as leads for potential pharmaceutical or agricultural fungicide development.
Technical Abstract: Piper is a big genus of the plant family Piperaceae, with more than 700 species widely distributed in the tropical and subtropical regions of the world. Some species are used in folk medicine as analgesics, antiseptics, insecticides, and antimicrobials or for the treatment of toothache, haemorrhoids, dysmenorrhea, and wound [1-4]. Extensive chemical studies on Piper species have resulted in the isolation of a large number of structurally diverse compounds. This review attempts to document chemical structures and antifungal activites of these compounds, with the aim of providing useful inforation for potential pharmaceutiacal or agricultural fungicide development. The antifungal compounds are classified into amides, flavonoids, prenylated benzoic acid derivatives, lignans, phenylpropanoids, butenolides, and cyclopentenediones.