Location: Warmwater Aquaculture Research UnitTitle: Single intravenous and oral dose pharmacokinetics of florfenicol in the channel catfish Ictalurus punctatus Author
Submitted to: Journal of Veterinary Pharmacology and Therapeutics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/24/2011
Publication Date: 9/20/2011
Publication URL: http://handle.nal.usda.gov/10113/55419
Citation: Gaunt, P.S., Langston, C., Wrzesinski, C.L., Gao, D., Adams, P., Couch, L.S. 2011. Single intravenous and oral dose pharmacokinetics of florfenicol in the channel catfish Ictalurus punctatus. Journal of Veterinary Pharmacology and Therapeutics. P.1365-2885. Interpretive Summary: The pharmacokinetics and pharmacodymanics of florfenicol given as an intravenous dose or as an oral dose were studied in the channel catfish Based on the results, it was concluded that an oral dose of 10mg florfenicol/kg body weight in channel catfish is an efficacious dose.
Technical Abstract: Plasma distribution and elimination of florfenicol in channel catfish were investigated after a single dose (10mg/kg) of intravenous i.v.) or oral administration in freshwater at a mean water temperature of 25.4°C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After i.v. injection, the terminal half-life (t1/2), volume of distribution at steady state (Vss),and central volume of distribution (Vc) were 8.25 h, 0.9 and 0.381 L/kg, respectively. After oral administration of florfenicol, the terminal t1/2 , Cmax, Tmax and oral bioavailability (F) were 9.11 h, 7.6µg/mL 9.2 h, and 1.09, respectively. There was a lag absorption time of 1.67 h in oral dosing. Results from these studies support that 10mg florfenicol/kg body weight in channel catfish is an efficacious dose following oral administration.