Page Banner

United States Department of Agriculture

Agricultural Research Service


Location: Mycotoxin Prevention and Applied Microbiology Research

Title: Proposal for a new ISHAM Working group on Clinical Fusarium

item Van Diepeningen, Anne
item Geiser, David
item Guarro, Josep
item Sutton, Deanna
item Pearlman, Eric
item O`donnell, Kerry
item Harak, Henry
item Summerell, Brett
item Najafzadeh, M. Javad
item Brandt, Mary
item Hennequin, Christophe
item Tortorano, Anna
item Schroers, Hans-josef
item Buot, Genevieve
item De Hoog, G. Sybren

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/15/2012
Publication Date: 6/15/2012
Citation: Van Diepeningen, A.D., Geiser, D.M., Guarro, J., Sutton, D.A., Pearlman, E., O Donnell, K., Harak, H., Summerell, B.A., Najafzadeh, M., Brandt, M.E., Hennequin, C., Tortorano, A.M., Schroers, H., Buot, G., De Hoog, G. 2012. Proposal for a new ISHAM Working group on Clinical Fusarium. Meeting Abstract.

Interpretive Summary:

Technical Abstract: Infections caused by Fusarium species can be classified in three classes: 1) Superficial infections of skin and nails; 2) Keratitis of the cornea; and 3) Deep and disseminated infections. Whereas the first two types of these opportunistic infections are generally seen in immunocompetent hosts, the deeper mycoses are mostly restricted to immunocompromised patients. Over the past three decades, clinical data suggest that the numbers of all types of infections caused by Fusarium species may be increasing. Most Fusarium species prove to be very resistant to the currently used antifungal drugs, although amphotericin B, posaconazole, and voriconazole show good activity against this genus. However, strains resistant to these compounds are regularly encountered, and combination therapy is frequently required. The prototype of Fusarium is a well recognizable fungus with clear banana-shaped macroconidia of variable sizes, the presence or absence of smaller microconidia of variable shape, and the presence or absence of chlamydospores. Some clinically relevant species may produce pigments (e.g., yellow-orange, red or violet) that are exuded into the medium. Fusarium comprises a complex cluster of different species and many species complexes, which can best be distinguished with the aid of DNA sequence data. Precise identification of species/multilocus haplotypes is important for diagnosis, treatment, and epidemiological purposes. Though roughly two-thirds of infections are caused by members of the Fusarium solani species complex, species within seven other species complexes have been reported to cause mycoses.Our aim is to study Fusarium infections both from the side of the infected host as well as from the pathogen side, to exchange knowledge and to provide tools and aids for rapid identification and treatment.

Last Modified: 10/18/2017
Footer Content Back to Top of Page