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ARS Home » Midwest Area » Peoria, Illinois » National Center for Agricultural Utilization Research » Bio-oils Research » Research » Publications at this Location » Publication #277959

Title: Synthesis of biologically active phosphonates from Lesquerella oil

item COLEY, CHELSEA - Knox College
item CERMAK, DIANA - Knox College
item FAYER, EFFRAT - Knox College
item Cermak, Steven - Steve

Submitted to: American Chemical Society National Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 1/30/2012
Publication Date: 3/25/2012
Citation: Coley, C.L., Cermak, D.M., Fayer, E.L., Cermak, S.C. 2012. Synthesis of biologically active phosphonates from Lesquerella oil. American Chemical Society National Meeting. CHED 212.

Interpretive Summary:

Technical Abstract: Bisphosphonates and vinyl phosphonates are two classes of compounds that have much potential, namely as pharmaceutical agents and synthetic building blocks. Previous studies have shown success in synthesizing these compounds from hydroxy fatty acids (HFAs) found in Ricinus communis, commonly known as castor. We have proposed the same synthetic plan for HFAs derived from Lesquerella fendleri. Using lesquerolic acid as our base HFA, we have modified the carboxyl moiety to produce two families of phosphonate derivatives. The synthesis of these derivatives will be presented.