Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 3/14/2013
Publication Date: 5/14/2013
Citation: Manthey, J.A., Cesar, T.B. 2013. Issues surrounding the anti-inflammatory actions of the citrus polymethoxylated flavones. In: Tropical and Subtropical Fruits: Flavor, Color, and Health Benefits. Eds. B.S. Patil, et.al., American Chemical Society Symposium Series. Vol. 1129 p.159-169. Interpretive Summary: The expression of anti-inflammatory effects following doses of citrus compounds, termed polymethoxylated flavones, depends on many factors. Results of our studies show that there may be differences in the bioavailabilities of different polymethoxylated flavones, and the physical state of these compounds may play important roles in controlling efficacy.
Technical Abstract: The polymethoxylated flavones in citrus have been evaluated for their in vivo anti-inflammatory actions in several animal assays. Strong anti-inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration.