Submitted to: Keystone Symposia
Publication Type: Abstract Only
Publication Acceptance Date: 11/23/2011
Publication Date: 1/17/2012
Citation: Liu, G. 2012. Analyses of cattle DNA methylation patterns in diverse tissues [abstract]. Keystone Symposia. p. 67.
Technical Abstract: We launched an effort to produce a reference cattle DNA methylation resource to improve animal production. We will employ experimental pipelines built around next generation sequencing technologies to map DNA methylation in culture cells and primary tissues systems frequently involved in animal production. These samples include muscle, mammary gland, rumen and digestion tract tissues. We expect to deliver a collection of normal DNA methylation that will provide a reference for comparison and integration with future studies. We plan to compare the distinct patterns in these diverse tissues. We also aim to integrate it with other epigenomics data such as histone modifications, chromatin accessibility and small RNA and mRNA transcripts to further our understanding in animal biology.