Submitted to: American Chemical Society National Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 10/30/2010
Publication Date: 3/27/2010
Citation: Edwards, J.V., Prevost, N.T., Condon, B.D., French, A.D. 2010. Exploring biomedical ppplications of cotton. American Chemical Society National Meeting. Talk was presented and recorded on March 27, 2011 and available online for one year at http://www.softconference.com/ACSchem/sessionDetail.asp? Interpretive Summary:
Technical Abstract: The use of cotton as a biomaterial for design of improved wound dressings, and other non-implantable medical textiles will be considered. The research and development of cotton-based wound dressings, which possess a mechanism-based mode of action, has entered a new level of understanding in recent years based on improved definition of the biochemical events associated with the wound healing cascade. Examples are witnessed with carbohydrate-based wound dressings, which have received increased attention in recent years for their mechanical and molecular interactive properties with the hemostasis and inflammatory stages of wound healing. Recently the molecular modes of action have been elucidated for both new dressing designs and accepted traditional designs as balancing the biochemical events of hemostasis in the form of hemorrhage control dressings and inflammation in the form chronic wound dressings to improve healing. The mechanism of action includes acceleration of thrombin production and down-regulation of destructive proteolysis. In particular recent efforts to design and employ active dressings accelerate thrombin production or to regulate proteolysis in the non-healing wound will be discussed.