Location: Mosquito and Fly ResearchTitle: Trifluoromethylphenyl Carboxamides as Mosquito Adulticides Author
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/13/2011
Publication Date: N/A
Citation: N/A Interpretive Summary: N/A
Technical Abstract: Twenty trifluoromethylphenyl carboxamides were synthesized and evaluated as mosquito adulticides. These compounds are safe, inexpensive to synthesize and are alternatives to current active ingredients found in commercial products. Compound structures were confirmed by TOF-MS, and 1H and 13C NMR spectroscopic analysis. Toxicity assays were performed using Ae. aegypti larvae and adults. The Minimum Effective Dosages (MED) for repellency was determined using adult female Ae. aegypti and Anopheles albimanus. Two compounds, N-(2,6-dichloro-4-(trifluoromethyl)phenyl)-3,5-dinitrobenzamide and 2-methyl-N-(3-(trifluoromethyl)phenyl)benzamide produced 100% mortality in Ae. aegypti larvae after a 24h exposure at a concentration of 100µM. An additional four compounds produced 100% mortality after 48h and one additional compound produced 100% mortality after 72h. A dose of 31.25 nmol/insect of 2,2,2-Trifluoro-N-(2-(trifluoromethyl)phenyl)acetamide produced significant knock-down and mortality in adult Ae. aegypti at 24 h post treatment. The LD50 estimate for this compound lies between 30 and 60 nmol per insect. This compound also had a MED that was 2.3 times lower than DEET against Ae. aegypti and another compound, N-(2-(trifluoromethyl)phenyl)hexanamide, had a MED comparable to DEET. Based upon the potency of these compounds, we plan to synthesize additional similarly structured compounds to study their insecticidal activity.